AQA Jan 2010 Paper 5 Q6

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the complex cisplatin acts as an anticancer drug by changing the properties of dna when it reacts with guanine a component of dna areas outside the box will not be scanned for marking cl cl pt nh nh connects to dna chain cisplatin guanine when cisplatin is absorbed into the human body it undergoes a ligand substitution reaction and one chloride ligand is replaced by a water molecule forming a complex ion q a write an equation for this substitution reaction to form the complex ion q marks b the complex ion q can bond to guanine in two different ways b i the first way involves a hydrogen atom from one of the ammonia ligands on q bonding to an atom in a guanine molecule state the type of bond formed to guanine and identify an atom in guanine that could form a bond to this hydrogen atom type of bond atom in guanine marks b ii the second way involves a ligand substitution reaction in which an atom in a guanine molecule bonds to platinum by displacing the water molecule from q state the type of bond formed between guanine and platinum when a water molecule is displaced and identify an atom in guanine that could bond to platinum in this way type of bond atom in guanine marks wmp jan chem c state and explain one risk associated with the use of cisplatin as an anticancer drug risk explanation marks areas outside the box will not be scanned for marking turn over for the next question turn over wmp jan chem

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