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CIE Nov 2014 v2 Paper 4 Q7
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![(a) Oseltamivir is an antiviral drug that slows the spread of the in uenza ( u) virus. 16 PMT HN NH2 oseltamivir Circle two bonds, each in a different functional group, that could be easily hydrolysed in the body. [2] (b) Oseltamivir is a chiral drug. This drug is usually taken as a single optical isomer rather than as a mixture of isomers. Suggest one bene t of taking a drug in this way.[1] (c) Oseltamivir is a competitive inhibitor of an enzyme produced by theu virus. Explain the meaning of the term competitive inhibitor and state how its action could be overcome.[3]UCLES 2014 9701/42/O/N/14<br />
PMT (d) ATP plays an important role in metabolic reactions in living organisms. 17 NH2 CH2O P H O O O P O O HO OH ATP What is the function of ATP in living organisms?[1] [Total: 7]UCLES 2014 9701/42/O/N/14 [Turn over<br />](https://learnah.org/wp-content/uploads/2018/08/November_2014_v2_QP_-_Paper_4_CIE_Chemistry_A-level_7-0.jpg)
![Page 11 Mark Scheme Syllabus Paper Cambridge International A LevelOctober/November 2014 9701 42 (c) any three of: (all can be awarded from a clear, labelled diagram) (base pairing) A to T OR C to GH-bonds between bases two/double stranded/chainsanti-parallel strands (general structure) sugar-phosphate backbone OR BASE-SUGAR-PHOSPHATE bonded in a diagram (d) van der Waals forces lost (in val) H-bonding gained (in ser) Total (a) amide group circled OR indicated as diagram ester group circled OR indicated as diagram CH CH CH NH CH CH PMT [3] [2] 11 [2] (b) lower doses of the drug required [1] OR improved activity of the drug OR reduced side effectsCambridge International Examinations 2014<br />
Page 12 Mark Scheme Syllabus Paper Cambridge International A LevelOctober/November 2014 9701 42 (c) decreases enzyme activity OR decreases rate at which product is formed binds with the enzymes active site OR has a complementary shape to active site OR similar shape to substrate (competitive inhibition can be overcome by) increasing [substrate] OR increasing substrate concentration (d) energy source/carrier OR releases energy when hydrolysed Total (a) M:M+1 = 100/(1.1 x n) 20.4/0.9 = 100/(1.1 x n) x =4 (ii) C4H10O (b) (i) 2-methylpropan-1-ol OR correct structure CH CH OH (ii) 0.9-1.0 is (2 x)CH3R/CH3/RCH multiplet/1.8 is CHR/R3CH singlet/2.5 is OH 3.4 is CH2O/CH3O (iii) doublet 1H/one proton on adjacent carbonCambridge International Examinations 2014 PMT [3] [1] [3]<br />](https://learnah.org/wp-content/uploads/2018/08/November_2014_v2_MS_-_Paper_4_CIE_Chemistry_A-level_7-0.jpg)
